|
S.No.
|
Chemical compound
|
How it interferes
|
Mechanism
|
|
1.
|
DCMU (3-(3,4-dichlorophenyl)-1,1-dimethylurea)
|
Inhibition
of electron transfer
|
Competes
with plasoquinone (QB) for binding site in PSII
|
|
2.
|
FCCP (cyanide-p-trifluoromethoxyphenylhydrazone;)
|
Uncoupling of phosphorylation from
electron transfer
|
Hydrophobic
proton carriers
|
|
3.
|
DNP(2,4-dinitrophenol)
|
Hydrophobic
proton carriers
|
|
|
4.
|
Valinomycin
|
K+
ionophore
|
|
|
5.
|
Thermogenin
|
In brown adipose tissue, forms
proton-conducting pores in
inner
mitochondrial membrane
|
|
|
6.
|
Atractyloside
|
Inhibition
of ATP-ADP exchange
|
Inhibits
adenine nucleotide translocase
|
|
7.
|
DCCD(dicyclohexylcarbodiimide)
|
Inhibition
of ATP synthase
|
Blocks
proton flow through Fo and CFo
|
|
8.
|
Aurovertin
|
Inhibits
F1
|
|
|
9.
|
Oligomycin
|
inhibits
Fo and CFo
|
|
|
10.
|
Venturicidin
|
||
|
11.
|
Cyanide
|
Inhibition of electron transfer
|
Inhibit cytochrome oxidase
|
|
12.
|
Carbon monoxide
|
||
|
13.
|
Antimycin A
|
Blocks
electron transfer from cytochrome b to cytochrome c1
|
|
|
14.
|
Myxothiazol
|
Prevent electron transfer from Fe-S
center to ubiquinone
|
|
|
15.
|
Rotenone
|
||
|
16.
|
Amytal
|
||
|
17.
|
Piericidin A
|
Source: Lehninger Principles of Biochemistry (Nelson and Cox, 6th edition)
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