Sunday, March 22, 2020

Coronavirus


Virus classification
Phylum                 incertae sedis
Order                   Nidovirales
Family                   Coronaviridae
Subfamily             Orthocoronavirinae

Species of Alphacoronavirus
Human coronavirus 229EHuman coronavirus NL63Miniopterus bat coronavirus 1 etc.
Species of Betacoronavirus
Human coronavirus HKU1, Severe acute respiratory syndrome-related coronavirus (SARS-CoV), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), Middle East respiratory syndrome-related coronavirus (MERS) etc.
Species of Gammacoronavirus
Infectious bronchitis virus etc.
Species of deltacoronavirus
Bulbul coronavirus HKU11 etc.

There are seven strains of human coronavirus, four strains of which produce the generally mild symptoms of the common cold:
1.   Human coronavirus OC43 (HCoV-OC43)
2.   Human coronavirus HKU1
3.   Human coronavirus NL63 (HCoV-NL63, New Haven coronavirus)
4.   Human coronavirus 229E (HCoV-229E)
and three strains cause severe symptoms:
1.   Middle East respiratory syndrome-related coronavirus (MERS-CoV), previously known as novel coronavirus 2012 and HCoV-EMC
2.   Severe acute respiratory syndrome coronavirus (SARS-CoV or "SARS-classic")
3.   Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019-nCoV or "novel coronavirus 2019"
Some interesting facts about SARS-CoV2:
·        Previously it was known as 2019 novel coronavirus (2019-nCoV)
·        SARS-CoV2 is responsible for pandemic COVID-19
·        Outbreak of SARS-CoV2 is declared as pandemic by WHO on March 11, 2020.
·        It is the seventh known coronavirus to infect people, after 229E, NL63, OC43, HKU1, MERS-CoV, and the original SARS-CoV.
·        Its transmission occurs by respiratory droplets like cough and sneeze within the range of 2 metre.
·        Size of SARS-CoV2 is 50-200nm in diameter.
·        SARS-CoV-2 has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope.
·        Spike protein is responsible for attachment of virus to host membrane.
·        Genome of SARS-CoV2 is positive-sense single-stranded RNA (+ssRNA).
·        Its genome is of 30kb length.
·        SARS-CoV2 bind with angiotensin converting enzyme2 (ACE2) receptors of human cells and enter into cells.
COVID-19 Update (till March 22, 2020 at 7:00 PM IST)

Total Coronavirus Cases: 317,298

Deaths:13,642

Recovered: 95,949
Active cases
Closed cases
207,707
Currently Infected Patients

109,591
Cases which had an outcome:

197,565 (95%)
in Mild Condition

10,142 (5%)
Serious or Critical

95,949 (88%)
Recovered / Discharged

3,642 (12%)
Deaths


COVID-19 Update (till March 22, 2020 at 5:30 AM IST)

Total cases
New cases
Total deaths
New deaths
Total recovered
Active cases
Serious, critical
Total cases/1M population
360
28
7
2
24
329

0.3

Outbreak of Coronavirus related diseases

Outbreak
Virus
SARS, 2003
SARS-CoV
MERS, 2012
MERS-CoV
MERS, 2015
MERS-CoV
MERS, 2018
MERS-CoV
COVID-!9
SARS-CoV2


Saturday, March 14, 2020

Definition of Pandemic, Endemic, Epidemic and Syndemic

Pandemic (from Gree pan "all" and demos "people") is a disease epidemic that has spread across a large region, viz. multiple continents, or worldwide. A pandemic is an epidemic occurring on a scale that crosses international boundaries, usually affecting a large population.

Endemic (from Greek en "in, within" and demos "people") an infection is said to be endemic in a population when that infection is constantly maintained at a baseline level in a geographic area without external inputs.

Epidemic An epidemic (from Greek epi "upon or above" and demos "people") is the rapid spread of disease to a large population in given population within a short period of time.

syndemic or synergistic epidemic is the aggregation of two or more concurrent or sequential epidemics or disease clusters in a population with biological interactions, which exacerbate the prognosis and burden of disease.

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